Autism Speaks Fellowship Grant awardee 2012-continuing
Goal & Interest: To gain in-depth knowledge in autism and identify novel biomarkers
- PhD in Biomedical Sciences, National Institute of Immunology & University of Delhi, Delhi, India
- Masters in Biotechnology, GGD central University, Bilaspur, India
- Bachelors in Biology, Utkal University, Orissa, India
2012-Autism Speaks Translational Postdoctoral Grant
2011-AOSpine South East Asia Research Grant, Co-investigator on the grant:
2010-Department of Science & Technology, DST Fast Track Young Scientist Award, Ministry of Science and Technology, Govt of India
2010-Fundamental Research Grant, Ministry of Education, Malaysia; Co-PI on the grant.
2000-2005: Defence Research Development Oraganization, DRDO Senior Research Fellowship, Govt. of India.
1998-1999: Department of Science & Technology, DST Junior Research fellowship, Govt. of India, All India Institie of Medical Sciences (AIIMs), New Delhi.
1) Decoding the transcript-to-metabolite crosstalks in hESC-derived neual progenitors using NMR-based metabolomics and RNA-seq based transcriptomics.
Metabolomics has emerged as an advanced tool to study metabolic circuits associated with the cell fate determination. Our lab is one of the few labs in the globe which focuses on deciphering the metabolic circuits involved in human neural progenitor cell fate decisions. To delineate metabolic signatures in stage specific differentiation of human embryonic stem cell into glutamatergic neurons, I have determined the metabolic patterns at each distinct stage of neuronal commitment using NMR-based metabolic profiling and RNA-seq mediated transcriptomics. Overall in silico mapping of these metabolic signatures to web based repertoires, has identified unique sets of metabolic fingerprints involved in neuronal fate commitment of hESCs and provided new knowledge on the metabolic biomarkers of neuronal development.
2) Integrative System Biology of iPSC-induced Neurons for Identifying Novel Drug Targets.
Emerging evidences suggests that autism is a result of the complex interaction of environmental factors and the genetic background. At the cellular level, such interaction can be manifested at the level of metabolites, small molecules essential for the proper cellular function. Indeed, many metabolic abnormalities have been associated with autism, such as carnitine deficiency and dysfunctions of mitochondria, cholesterol metabolism, and the tryptophan-nicotinic acid metabolic pathway. Based on the published and clinical data from our lab, I aim to decipher the crucial metabolic biomarkers specific to autism in patient-iPSC derived glutamatergic neurons and microglia. Towards this end I have generated iPSC from syndromic and idiopathic autistic cohorts, and currently studying the glutamatergic neuronal commitment in these samples.